Objective To evaluate the incidence of depress in hemodia lysis and peritoneal dialysis uremia patients. Methods Forty hemodialysis and 36 peritoneal dialysis pati ents were measured by HAMD, compared the HAMD marks between two groups. Results The incidence of depress in hemodialysis (80%) was significantly higher than that in the peritoneal group(69%), the severe depress rate was the same(25% vs 12%). Conclusions Hemodialysis can cause somatic symptom and wor sen psychologic obstacle, meanwhile treating uremia.