Objective To investigate the clinical effect of low-calcium dialysate in the treatment of the hypercalcemia of hemodialysis patients. Methods Low-calcium dialysate (1.25mmol/L) was used in 24 hemodialysis patients of hypercalcemia. Results There were significant difference between low-calcium dialysate was used before and after three months and six months in blood calcium ( P＜0.05）, and there were also significant difference in Ca×iP (P＜0.05）. There were no singnificant difference in blood phosphorus (P＞0.05) and in iPTH (P＞0.05). Conclusion There were significant difference between low-calcium dialysate was used before and used after three months and six months in blood calcium with hypercalcemia. It is effect to reduced calcium transfer from body's bone to other body's organs.