Objective To investigate the effect of hemoperfusion (HP) on lipids in hemodialysis patients with chronic renal failure(CRF). Methods To compare the differences of lipids in 40 hemodialysis patients with CRF before and after the treatment of combined hemodialysis-hemoperfusion. Results Lipid disorders are common in patients with CRF. The levels of triglyceride(TG) and lipoprotein(a)［Lp(a)］ in serum decreased after the treatment of combined hemodialysis-hemoperfusion. The levels of cholesterol(TC)、high-density lipoprotein(HDL)、low-density lipoprotein(LDL)、apolipoprotein A (APOA)、APOB had no significant changes after treatment. Conclusion Hemoperfusion is a method of an effective treatment in dyslipidemia of hemodialysis patients.