Objective To investigate the effects of secondary hyperparathyroidism and abnormity of calcium-phosphorus matabolism on residual renal function in long-term hemodialysis patients. Methods The pulse pressure，serum calcium,phosphorus, PTH, ALP, TG, fasting blood sugar, Hb, LVMI and oral administration of Calcitriolum were counted in 140 cases of hemodialytic patients.The relation of those to RRF was analyzed. Results There were 63.6% hemodialytic patients suffered from secondary hyperparathyroidism. The levels of phosphorus, calcium-phosphorus product（P<0.01）, ALP, pulse pressure, LVMI, TG，fasting blood sugar（P<0.05） were higher and the level of Hb（P<0.05） was lower in the hyperparathyroidism patients than in other patients.There were negative correlation（P<0.05） between phosphorus，calcium-phosphorus product, PTH and Ccr in all of the patients.There were positive correlation（P<0.05） between ALP, pulse pressure, LVMI, TG, fasting blood sugar and PTH in all of the patients. There was negative correlation （P<0.05） between Hb and PTH in all of the patients.The levels of PTH、ALP、pulse pressure、LVMI、TG、fasting blood sugar were lower（P<0.01） and the levels of calcium, Ccr，Hb （P<0.05） were higher in the patients who were given Calcitriolum than in the subjects who were not given Calcitriolum.Conclusion The effects of secondary hyperparathyroidism and abnormity of calcium-phosphorus matabolism on residual renal function, cardiovasculir system,endocrine system, hematopoietic system, skeleton in hemodialytic patients is significant. Calcitriolum can slow down the deterioration of RRF.