Objective To investigate the clinical efficacy of hemoperfusion on chronic severe liver diseases. Methods Total eight patients with hepatic encephalopathy of chronic severe hapatitis or liver cirrhosis were treated by charcoal hemoperfusion. Results Clinical features of hepatic encephalopathy after treatment were significantly improved. Total bilirubin and blood ammonia was significantly decreased. Conclusion Charcoal hemoperfusion, which may result in early recovering of consciousness, is useful in patients with chronic severe liver diseases and has been suggested as a bridge to liver transplantation. However further study is still required.