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Chinese Journal of Blood Purification ›› 2005, Vol. 4 ›› Issue (10) : 531-534.

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Abstract

Objective To investigate the effects of the low calcium dialysate on the serum calcium(Ca), phosphate(P), Calcium-phosphate product(Ca×P) and iPTH in hemodialysis patients with different PTH level. Methods Twenty-seven maintenance hemodialysis patients who were hypercalcaemia were divided into three groups according to different iPTH level: group I: iPTH＜120 pg/ml, with low turnover bone disease (LTBD); group II: iPTH 120～600pg/ml; group III: iPTH＞600pg/ml with severe secondary hyperparathyroidism need the active vitamin D therapy. Low calcium dialysate(1.25mmol/l) were applied to the patients three months.The variety of Ca, P, (Ca×P) and iPTH were applied to. Results After using the low calcium dialysate, Ca of the three groups before and ofter hemodialysisly decreased significant (P＜0.05 and P ＜0.01 respectively ); there were no significant difference of P(P＞0.05); Ca×P decreased significantly (P＜0.05); iPTH of group I significant increased (P＜0.05); iPTH of group II and group III increased slightly, but there were no significant difference( P＞0.05). The rates of adverse reaction is 6/27(22.2%), include muscle spasm, hypotension and arrhythmia. Conclusions In the hemodialysis patients with hypercalcaemia, include different reasons as active vitamin D therapy and LTBD, Using of the individual low calcium dialysate can decrease Ca and. Ca×P We should pay attention that low calcium dialysate may increase PTH severetion.