PDF(320 KB)

Chinese Journal of Blood Purification ›› 2005, Vol. 4 ›› Issue (10) : 542-544.

论著

Author information +

History +

Abstract

objective To study the effect of a various degree of renal disfunction on plasma homocysteine (Hcy) and its potential relationship to plasma creatinine concentration and cardiovascular diseases and probe into their clinical significance. Methods Plasma Hcy concentration in 98 patients with the various degree of chronic renal failure (CRF) and 40 healthy controls were measured by rapid microcolumn high pressure liquid chromatography in DS30. Results The incidence of hyperhomocysteinemia in the patients with CRF is 86.7% and 32.3 times higher than that in healthy individuals, P ＜0.01. Linear regression analysis showed a significant correlation between plasma Hcy and creatinine concentration (r=0.358, P ＜0.01) or creatinine clearance (r=-0.362, P＜0.01). Mean plasma Hcy concentrations in post-HD decreased by 34.1% compared with that in pre-HD and significantly higher than controls, P＜0.01. Mean plasma Hcy levels in CRF with cardiovascular (CVD) are significantly higher than that in the patients with non-CAD, P＜0.01. Conclusions Hyper-homocysteinemia is common in the patients with a various degree of CRF. Plasma Hcy concentration in CRF is significantly related to the degree of renal failure. Increased plasma Hcy may be a risk factor for CAD in the patients with CRF.