Abstract: Objective To observe clinical effect of DNA280 immunoadsorbent on systemic lupus erythematosus (SLE) patients. Methods Strictly according to the standard of inclusion and exclusion, selecting 30 patients with SLE patients to accept immunoadsorption therapy and detect the titres of ANA and ds-DNA in pre-treatment and after-treatment, Morever, the concentrations of IgA、IgG、IgM antibody 、C3、C4 and the change of blood routine 、electrolyte 、renal function、hepatic function，then analyzed results by statistics, P＜0.05 was considered as significant difference. Results the titres of ANA and ds-DNA decreased after treatment which was significant difference compared with pretreatment(P＜0.05)；the parameters of blood routine, biochemical indicator remained static without obvious liver and nephron function loss.The clinical symptoms were improved. Conclusion DNA280 immunoadsorbent has definitely better therapeutic effect which can exclusively decrease the levels of ANA、ds-DNA. The immunoadsorption is safe and no obvious side effects.

Key words: Immunoadsorption, Systemic lupus Erythematosus, Antinuclear antibody(ANA), Anti-DNA antibody(ds-DNA)