Objective To investigate serum high sensitive C-reactive protein(hs-CRP) level and its correlation with the nutritional status and the heart structure in maintenance hemodialysis(MHD) patients. Methods This study included 72 MHD patients who were followed-up for more than 3 months in our dialysis center. The serum levels of hs-CRP, hemoglobin, albumin, prealbumin, transferin, triglyceride, cholesterol were determined. The left atrial diameter and interventricular septum thickness, left ventricular posterior wall thickness were measured by echocardiography. These patients were divided into elevated hs-CRP group(hs-CRP≥3mg/L）and normal hs-CRP group（hs-CRP＜3mg/L）. The associations between hs-CRP and nutrition status and the heart structure were analyzed respectively. Results Hb, Alb, preAlb and TF concentration were significantly lower in elevated hs-CRP group. There were negative relationship between hs-CRP and Hb, Alb, preAlb, TF and positive relationship between hs-CRP and left ventricular diameter and interventricular septum thickness, left ventricular posterior wall thickness respectively. Conclusion hs-CRP might be a marker for the nutrition status and ventricular hypertrophy.