Objective We quantitatively described the sodium removal with low-sodium dialysis solutions to prevent the development of sodium and fluid retention in peritoneal dialysis patients. Methods Kinetic model of sodium removal during single dwell time was established according to three-pore model, and by which the sodium removal with low-sodium dialysis solutions was analyzed. The appropriate sodium concentration in dialysis solutions was discussed. Results More than 0.23g sodium could be removed with 5 mmol/l of decrease in dialysate sodium concentration. The appropriate sodium concentration in dialysis solution may be about 128 mmol/l. Conclusion Our result demonstrated that low-sodium solution could significantly increase sodium removal.