Objective To investigate the therapy effect of continuous blood purificatious for infection shock patients. Methods Twenty-four infectious shock patients received continuous veno-venous hemofiltration (VVH) therapy hospitalized in ICU department from oct. 2002 to Oct. 2004 were investigated. The patients' pH value, HCO-3, BE, blood urea nitrogen (BUN), creatinine (Cr), blood pressure, APCHE-III scores, oxygenic index and dosages of asoactive drugs used before and after CVVH were observed. Results In the 24 patients, 13 survived and 11 died, the death rate was 45.8%. After receiving CVVH therapy, all patients' APCHE-II scores and biochemical paramenters were improved, dosage of vasoactive drugs were reduced. Conclusions For infectous shock patients, early continuous blood purification therapy may avoid multiple organ dysfunction syndrom (MODS) and improve porgnosis.