Objective To study the relationship between hypertension and fluid removal in peritoneal dialysis (PD) patients. Methods In this cross-sectional study, 170 stable PD patients in our center were studied. According to the degree of peripheral edema, they were divided into three groups: group 1 without edema (n=65), group 2 with mild edema (n=80) and group 3 with moderate edema (n=25). The total fluid and sodium removal were measured. The bioimpedance analysis was employed to assess the extracellular water (ECW), intracellular water (ICW) and total body water (TBW). Result The difference of total fluid and sodium removal, blood pressure were statistically significant between the three groups: the more severe the peripheral edema, the higher the total fluid and sodium removal, the higher blood pressure, the higher ECW and TBW. Conclusion This study showed that PD patients with more fluid and sodium removal was not necessarily related to good blood pressure control, which indicated that fluid and sodium restriction was important in control hypertension in PD patients.