Objection Evaluate the therapeutical effect of non-renal refractory heart failure by continuous renal replacement therapy (CRRT). Methods The variation of the clinical symptom and noninvasive cardio dynamics of the patients whose non-renal refractory heart failure were treated by CRRT was observed. Result Effective rate of 35 cases treated by CRRT is 82.9%. Noninvasive cardio dynamics and clinical index improved significantly post-therapy. Conclusion CRRT is an effective method to treat non-renal refractory heart failure.