Objective We proposed a new blood purification modalityhemodialysis with plasma-based dialysate(HD-PBD) plus high volume hemofiltration(HVHF) for patients with hyperbilirubinemia,and evaluated the effect of this treatment on removal of serum bilirubin. Methods Seven patients with hyperbilirubinemia were included in this study.After HD-PBD for 6 hours,then treated with HVHF for 24 hours with the same filter. Six patients treated with molecular adsorbent recirculating system (MARS) were as controls. Serum total bilirubin(TB), direct bilirubin(DB) and indirect bilirubin(IB) were detected before and after treatment in all patients. Arterial blood gas analysis and the concentration of electrolytes in all patients were monitored before and after treatment. Results HD-PBD for 6 hours is more effective in the removal of serum bilirubin than HVHF for 24 hours（P<0.05）. There were no significant diffevence of arterial blood HCO-3, PCO2, PO2 and electrolyte before and after HD-PBD （P>0.05）, and aforementioned target is significanly different before and after HVHF （P<0.05）. The average level of serum bilirubin was significantly increased in 1 to 2 days after MARS, but there was a significant decrease after HVHF for 24hours following HD-PBD（P<0.05）. Conclusion HD-PBD plus HVHF, a newly proposed modality for patients with hyperbilirubinemia, Which combines the predominance in removal of serum bilirubin and excellent correction of electrolyte and acid-base disturbance, is a low-cost, safe, simple and convenient treatment, and deserve to be generalized in clinical application.