Objective To develop an improved model of peritoneal dialysis in animal that mimic human peritoneal dialysis. Methods The study was done in male SD rats, animals were divided into four groups: normal rats (group 1) and sham operated rats (group 2) and dialysized rats exposed to PD solution4.25% (group 3) and 1.5% (group 4) respectively. The catheters implanted in dialysis rats were tunneled subcutaneously to the back and exchanged PD solutions 30ml per rat without anesthesia in two hours a day. At the first week and the fourth week of the study, the samples of blood were taken from these rats in each group to test serum creatinine and urea nitrogen and albumin, meantime, the body weigh and the mount of exchanged PD solutions were examined. Results All rats underwent PD could be administrated to exchanged PD solution repeatedly, the complications were peritonitis, catheter obstruction and /or dislocation, the rats that could not undergo PD were replanted the catheter to continue PD. The exchanged solution in the first week and the fourth week were similar between group 3 and group 4. Conclusion The conscious rat model for PD does allow regular fluid drainage, and it is a drainage model that mimiced human peritoneal dialysis.