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Chinese Journal of Blood Purification ›› 2005, Vol. 4 ›› Issue (8) : 427-430.

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Abstract

Objective To observe the effect of removing serum phosphate in maintenance hemodialysis patients with different kinds of dialyzers and modes of blood purification retrospectively.Methods Sixty-seven patients (28 male,39 female),median age (58.4±14.5) years, who received long-term hemodialysis were enrolled. We collected 1 year clinical and dialysis data and analyzed the levels of serum phosphate before and after dialysis with different kinds of dialyzers and different modes of blood purification retrospectively.Results The serum phosphate levels had no significant difference between hemodialysis (HD) and hemofiltration (HF) patients before blood purification. The level of serum phosphate of HF group decreased significantly compared with that of HD group after blood purification (P＜0.001). The serum phosphate levels of different dialysis membrane group had no significant difference before blood purification. The mean of serum phosphate in hemophan (HE) group decreased greatly comparing with those of polysulfon (PS) group and cellulose acetate (CA) group after blood purification (P＜0.05). The levels of serum phosphate were no significant difference among all groups of different hematocrit before blood purification. When hematocrit was less than 25% (group A), the decline rate of serum phosphate raised mildly with increased hematocrit. When hematocrit was more than 25.00%, the clearance rate of serum phosphate decreased with increased hematocrit. The mean of serum phosphate in group B (the range of hematocrit:25.00%～29.99%) decreased greatly comparing with that of group D (hematocrit:≥35.00%) after blood purification (P＜0.05). Conclusion Phosphate removal of HE membrane was better than CA membrane and PS membrane. Phosphate elimination by HF was much better than that by HD. When hematocrit was less than 25.00%, the decline rate of serum phosphate raised mildly with increased hematocrit. When hematocrit was more than 25.00%, the clearance rate of serum phosphate decreased greatly with increased hematocrit.