Objective To explore the strategies of using adjustable Objective To explore the strategies of using adjustable dialysate temperature and sodium concentration to reduce the occurrence of intradialytic hypotension and observe its clinical effects. Methods Four out-patients in our unit who had received haemodialysis for more than 6 months shown symptomatic hypotension in more than 3/4 episodes of treatment, with a than 25% reduction and /or lower than 100mmHg of systolic blood pressure needing medication were selected to participate this experiment. Each patient underwent cool-temp and high-sodium, cool-temp and standard-sodium, standard -temp and high-sodium, standard-temp and standard-sodium dialysis for 3 times respectively, and MAP were monitored during the process. Microsoft Excel was used to enroll and collect the data, SPSS software was used to do Test of Homogeneity of Variance and One-Way ANOVA, and statistical significance was defined as P＜0.05. Results One-Way ANOVA of the MAP data during and after haemodialysis in the 4 cases showed that there were significant differences at the level of P＜0.05 in each group. Post Hoc Multiple Comparisons of the MAP during haemodialysis in each group using LSD method showed that there were significant differences at the level of P＜0.05 between standard-temp and standard-sodium dialysis group and other three groups. Post Hoc Multiple Comparisons of the MAP during haemodialysis in each group using Tamhane method showed that there were significant differences at the level of P＜0.05 between cool-temp and high-sodium dialysis group and standard-temp and high-sodium, standard-temp and standard-sodium dialysis group. Conclusion cool-Temp and high-sodium dialysis improves tolerance for dialysis in hypotensive patients and helps increase ultrafiltration while maintaining haemodynamic stability during and after dialysis. Patients?perceptions were positive. The use of cool dialysate is a simple, useful and economical procedure, especially for highly symptomatic patients.