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Chinese Journal of Blood Purification ›› 2006, Vol. 5 ›› Issue (1) : 19-20.

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Abstract

Objective To observe the effects and differences of simvastain on serum lipids and inflammatory markers in patients with uremia. To investigate the treatment effects of simvastain on microinflammation state in patients with uremia. Methods In 64 patients with uremia and 30 healthy controls the level of C-reactive protein (CRP)、Interlukin-6 (IL-6)、serum lipid level were determined ,then the patients were randomly divided into 2 groups to receive simvastatin 20mg daily or nonlipid-lowering therapy.All above parameters were assayed again after 24 weeks. Results 1.Compared with healthy controls, the serum TG、IL-6、CRP were elevated significantly in patients with uremia.2. After 24 weeks’treatment, thelevels of TG、TC、CRP and IL-6 in simvastatin group were lower than before,and the level of CRP、IL-6 was much lower in simvastatin group than non- simvastatin group (P＜0.05). Conclusion Simvastatin can relieve the microinflammation state in patients with uremia.