PDF(325 KB)

Chinese Journal of Blood Purification ›› 2006, Vol. 5 ›› Issue (1) : 21-23.

论著

Author information +

History +

Abstract

Objective To study the therapeutic efficacy of hemoperfusion(HP) and dimercaprol in rescuing patients with acute tetramine poisoning and dynamic variations of β-endorphin（β-EP），endothelins（ET），nitrogen monoxide（NO）and tumor necrosis factor（TNF）in serum Methods ①Thirty-nine patients with acute tetramine poisoning (group C and B group）were enrolled in this study．Theirβ-EP，ET，NO and TNF were measured upon hospitalization and 1d、3d、5d、7d、9d、11d after hospitalization respectively．②They all received routine therapy, such as diazepam, phenobarbital sodium etc patients in group C and group B rereived dimercaprol. Hemoperfusion was applied in group C.Group A received routine therapy only. Results ①The levels of β-EP，ET，NO and TNF from 35 patients who were cured peaked at hospitalization in group C, and 1d after hospitalization in group B，then decreased gradually．The levels of β-EP，ET，NO and TNF after rescuing in C group were significantly less than those of group B. ②The efficiency in group C and group B were significantly higher than in group A,the accumulative amount of diazepam and phenobarbital，the eclampsia duration in group C were significantly less than those of group A and B,and group B were significantly less than those of group A. Conclusion The therapeutic efficacy of hemoperfusion and dimercaprol in rescuing patients with acute tetramine poisoning is better than dimercaprol and routine therapy only. It decrease levels of β-EP，ET，NO and TNF significantly，and can be considered as a better therapeutic method on treating tetramine poisoning.