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Chinese Journal of Blood Purification ›› 2006, Vol. 5 ›› Issue (11) : 776-778.

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Abstract

Objective To investigate the relationship between methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and cardiovascular and cerebrovascular diseases (CVD) in hemodialysis（HD）patients. Methods The technology of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect MTHFR gene C677T polymorphism in 74 HD patients and 30 healthy controls. Results Mean age in HD patients without CVD was significantly lower than that in HD patients with CVD. However, mean levels of serum creatinine in HD patients without CVD were significantly higher than that in HD patients with CVD. The frequency of MTHFR T allele in HD patients with CVD was significantly higher than that in healthy controls (39.6% vs.18.3%, P＜0.05). The frequencies of MTHFR T/T genotype among HD patients with CVD, HD patients without CVD and control subjects were 20.8%, 12.0% and 6.7%, respectively. There was no significant difference in the distributions of MTHFR T/T genotype (P ＞0.05). Conclusion This study can’t confirm that MTHFR T/T genotype is one of the genetic risk factors for CVD occurrence in HD patients.