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Chinese Journal of Blood Purification ›› 2006, Vol. 5 ›› Issue (3) : 132-133.

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Abstract

Objective to explore the influence of short term treatment of Simvastatin on inflammation in peritoneal dialysis patients. Methods Fourty-eight stable peritoneal dialysis patients were enrolled in this study as treated group, and another 20 health volunteers as controls. Some serum examinations which included total cholesterol, LDL cholesterol, HDL cholesterol, Triglycerides, creatine kinase(CK), aspartate aminotransferase(AST) and some inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and interleukin-10 (IL-10) were performend in the patients before and after 8 weeks treatment of Simvastatin and inthe cotrols. Results compared with the controls, high lipidemia and inflammatory status existed on peritoneal dialysis patients, but after 8 weeks treatment of Simvastatin, the total cholesterol, LDL cholesterol and triglycerides declined Significantly and the HDL cholesterol raised significantly(P＜0.05)；inflammatory factor such as hs-CRP and IL-6 declined significantly, P＜0.05 and P＜0.05, respectively; and the anti-inflammatory factor IL-10 raised significantly, P＜0.05. Conclusion There is significant anti-lipidemic and anti-inflammation effect of Simvastatin in peritoneal dialysis patients.