Objective To evaluate the therapeutic effect of haemoperfusion (HP) in treating patients with pulmonary injury after Paraquat(PQ) poisoning. Methods Fourty-nine patients were studied retrospectively. Of them, 27 patients received HP therapy(HP group), and the other 22 patients did not (control group). Pulmonary function were evaluated by detecting PaO2, SaO2, PacO2，VC, FVC, FEV1, X-ray changes in chest before and after HP therapy, the incidence of ARDS and MODS were compared. Results In HP group, the incidence of hypoxemia and type I respiratory failure was lower than that in control group (P＜0.05 and P＜0.01 respectively), the incidence of restrictive hypoventilation and diffuse dysfunction dereased, and manifestions in chest X-ray were lightened after treatment. Patients with MODS with without ARDS when permitted aggravated rapidly and had a poor prognosis. Conclusion Performing HP as soon as possible can not only ameliorate the pulmonary injury but also promote the absorption of vesicle and interstitial exudates, decelerate the formation of pulmonary fibrosis.