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Chinese Journal of Blood Purification ›› 2006, Vol. 5 ›› Issue (6) : 304-307.

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Abstract

Objective To investigate the effect of α-ketoacid supplemented low-protein diet therapy on protecting residual renal function(RRF) of patients with continuous ambulatory peritoneal dialysis(CAPD) prospectively. Methods Seventy-eight CAPD patients who were randomly assigned to a low-protein diet supplemented with α-ketoacid group(ketoacid group,31 patients), low-protein diet group(LPD groupe,26 patients) and routine protein diet group(RPD group,21 patients) were investigated and followed-up for one year. The serum levels of albumin(Alb), prealbumin(PA), transferrin (TF), retinal-binding-protein,(RBP),total cholesterol (TC),triglyceride (TG),phosphorus (P+++),intact parathyroid hormone (iPTH) were measured. Examinations of RRF,mean arterial pressure(MAP), peritoneal ultrafiltration(UF),residual urine volume(RUV) and the status of water-sodium retention were performed at baseline,median and at the end of the follow-up. Results There were no significiant differences in MAP,UF and peritoneal dialysate albumin loss between these groups.However,the trend of peritoneal dialysate albumin loss in ketoacid group and LPD group was descendent. Proteinuria decreased most significantly in ketoacid group(P＜0.01).Compared to low-protein diet group,serum levels of PA,RBP,TRF had a significant increment both in ketoacid group and routine protein diet group(P ＜0.01), but there was no significance between these two groups(P ＞0.05).There was an incremental tendency in Alb,TC,TG,but no significance(P ＞0.05). Compared to RPD group, levels of RRF, RUV were significantly higher both in ketoacid group and LPD group(P ＜0.01) There was an decrease tendency in P and iPTH,but no significance among three groups(P＞0.05).Conclusion α-ketoacid supplemented low-protein diet therapy have a tendency of protecting RRF in CAPD patients while maintaining patients in good nutritional state.