Abstract: Objective To observe levels of serum inflammatory factors and effect of hemoperfusion (HP) on acute renal failure(ARF) patients. Methods Seventy-six patients with simple ARF(without acute or chronic infection, malignancy,multiple organ failure,glucocorticoid and immunosuppressant treatment,history of blood transfusion)were randomly divided into hemoperfusion combined with hemodialysis (HD) group (HP+HD group, n=38) normal control group consisted of 25 healthy people. The serum CRP, IL-6 and TNFα levels of all patients and controls were detected by ELISA before and after the treatments. Results The serum CRP, IL-6 and TNFα levels in both treatment groups were significantly higher than those in control group(P＜0.001), and there were no significant difference between two treated groups before treatment(P＞0.05). The levels of CRP, IL-6 and TNFαhad significant positive correlation in all groups(P＜0.001); The serum CRP,IL-6 and TNFα levels decreased after treatment, and there was significant difference in HP+HD group (P＜0.001), but not in HD group (P＞0.05). Conclusion There are high levels of microinflammatory factors such as CRP, IL-6 and TNFαin ARF patients, which may be the evidence of microinflammatory state in ARF patients as CRF patients. The study also suggests that HP is an effective method to remove increased inflammatory factors in ARF patients.

Key words: Acute renal failure, Microinflammatory state