Abstract
Objective To investigate the effect and possible mechanism of ligustrazine in treating peritoneal fibrosis of experimental rats. Methods The peritoneal fibrosis rat model was induced by high glucose dialysate (4.25%,Baster) and lipopoly saccharide(LPS). The rats were randomly divided into three groups: Control group peritoneal fibresis,model group,and ligustrazine treating group.The ligustrazine treating group received daily intraperitoneal injection of 40mg/kg ligustrazine.Thirty days later all rats were sacrificed. The abdominal membrane was stained with HE and Masson method. Transforming growth factor β(TGF-β)in blood and dialysate were detected by ELISA method.Results The peritoneum visceral of peritoneal fibresis model group was thicker than that of ligustrazine treating group, and the concentration of TGF -βalso decreased obviously in ligustrazine group trating group. Conclusion Ligustrazine are beneficial to the prevention and treatment of peritoneal fibrosis.
Key words
Ligustrazine /
Transforming growth factor –β
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