Abstract: Objective To investigate the effect and possible mechanism of ligustrazine in treating peritoneal fibrosis of experimental rats. Methods The peritoneal fibrosis rat model was induced by high glucose dialysate (4.25%,Baster) and lipopoly saccharide(LPS). The rats were randomly divided into three groups: Control group peritoneal fibresis,model group,and ligustrazine treating group.The ligustrazine treating group received daily intraperitoneal injection of 40mg/kg ligustrazine.Thirty days later all rats were sacrificed. The abdominal membrane was stained with HE and Masson method. Transforming growth factor β(TGF-β)in blood and dialysate were detected by ELISA method.Results The peritoneum visceral of peritoneal fibresis model group was thicker than that of ligustrazine treating group, and the concentration of TGF -βalso decreased obviously in ligustrazine group trating group. Conclusion Ligustrazine are beneficial to the prevention and treatment of peritoneal fibrosis.

Key words: Ligustrazine, Transforming growth factor –β