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Chinese Journal of Blood Purification ›› 2007, Vol. 6 ›› Issue (1) : 14-16.

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Abstract

Objective To investigate the expression and significance of platelet activation in maintenance hemodialysis (MHD) patients with or without hypertension. Methods The expression of CD62P in blood of 24 hypertension MHD patients and 24 non-hypertensive MHD patients were assessed by flow cytometry, and compared with that of 20 normal controls. At the same time the platlet count (PLC) was determined in three groups. Results Compared to control group,CD62P level was significantly higher in hypertensive MHD patients [(18.92±12.71)vs(2.78±1.04),P＜0.01]and non-hypertensive MHD patients [(13.84 ± 8.51) vs (2.78±1.04), P ＜0.01]. The level of CD62P in hypertensive MHD patients, was significantly higher than that in no hypertensive MHD patients[(21.67±9.54) vs (13.84±8.51),P＜0.01). There was no significant difference of the level of PL among the three groups. Conclusion Expression of platelet activation in MHD patients are abnormal，especially in hypertensive MHD patients with maintenance hemodialysis.