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Chinese Journal of Blood Purification ›› 2007, Vol. 6 ›› Issue (1) : 17-19.

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Abstract

Objective To evaluate the efficiency and security of combining reduced calcium dialysate and 1，25(OH)2D3 with calcium carbonate on treating secondary hyperparathyroidism in maintenance hemodialysis (MHD) patients. Methods Twenty-three MHD patients with corrected serum calcium above 8.00mg/dl and intact PTH above 300pg/ml,were divided into 2 groups.One group with iPTH 300～600pg/ml received 1，25(OH)2D3 2～3μg/w, another group with iPTH 600～1000pg/ml received 1，25(OH)2D3 4～6μg/w. Calcium carbonate and reduced calcium dialysate (dialysate Ca2+:1.25mmol/l) were used at the same time.The full course of study was 20 weeks. The serum calcium, phosphorus, calcium-phosphorus product, iPTH and AKP were used at the same time and the variance of drug dosage before and during the study period were recorded. Results After 20 weeks’treatment, the serum phosphorus,calcium-phosphorus product and iPTH level were decreased significantly in the secondary hyperparathyroidism patients, the serum calcium level was stable during the study period. Side effects were minimal and could be well tolerated. Conclusion 1，25(OH)2D3 with reasonably adjusted dosage combined with calcium carbonate and reduced calcium dialysate are effecfive and safe therapy ofr secondary hyper-parathyroidism.