Objective To investigate the effects of continuous venovenous hemofiltration (CVVH) on the change of hemodynamics in patients with systemic inflammatory response syndrome (SIRS) and acute renal failure (ARF). Methods Sixteen patients with SIRS and ARF in intensive care unit of our hospital were scheduled for the treatment of CVVH. All patients were satisfied the criteria of SIRS and ARF. Except for routine monitors, mean invasive arterial pressure was monitored,and arterial blood gas analyzed by the catheter of radial artery. The change of hemodynamics was monitored by Swan-Ganz catheter, which was put in through the right jugular vein. A double trunk catheter was put into the right femoral vein and the CVVH was done with the Diapact CRRT (Braun, Germen). PS hemofilter(1.2m2) was applied. The HR, MAP, PAWP, CVP, CO, CI, SVR and PVR, blood biochemical markers including electrolytes, urea nitrogen and creatinine, arterial blood gas were recorded or measured at 0h, 2h, 4h, 6h following CVVH and 6h post-CVVH. Results No significant difference was found in the parameters of hemodynamics except for HR significant decrease following CVVH. BUN, Scr and serum K+ levels decreased significantly following CVVH. Conclusion CVVH could impove the blood biochemical markers including BUN、Scr and serum K+ with little harmful effect on hemodynamics in patients with SIRS/ARF.