Abstract:

Objective To explore high-flux hemodialysis (HFHD) on changes of event-related potentials P300, and the value of HFHD in improving cognition function in maintenance hemodialysis patients. Methods We treated 68 patients with end stage renal disease on maintenance hemodialysis and assigned them into 2 groups: high-flux hemodialysis group (n=38) and conventional hemodialysis group (CHD, n=30). The latency and amplitude of P300 were examined before treatment and after the treatment for one year. Results Before the treatment, the latency and amplitude of P300 were 398.6±38.5ms and 7.3±1.21μv, respectively, in HFHD group, and were 410.3±49.7ms and 6.9±1.03μv, respectively, in CHD group. No significant differences were found between the 2 groups (P>0.05). After the treatment, the latency and amplitude of P300 were 320.6±31.95ms and 8.5±1.02μv, respectively, in HFHD group, and were 390.6±42.8ms and 6.5±1.12μv, respectively, in CHD group. The differences between the 2 groups were statistically significant (P<0.01). Conclusions In maintenance hemodialysis patients using HFHD, changes of P300 latency and amplitude were significant, as compared with those using CHD. Therefore, HFHD may improve cognition function in maintenance hemodialysis patients.

Key words: End stage renal disease, Event-related potentials