Abstract
Objective To investigate serum resistin in maintenance hemodialysis (MHD) patients and to explore its correlation to microinflammatory state and lipid metabolism． Methods Serum resistin, biochemical parameters and related inflammatory factors were determined by ELISA in 30 MHD patients before and after hemodialysis and in 30 healthy individuals. Clinical data were collected, and the relationship between serum resistin and the parameters was investigated. Results Serum resistin increased significantly (5.88±2.54ng/ml vs. 1.94±0.95ng/ml, P＜0.01) in MHD patients, especially in those complicated with cardiovascular diseases. In MHD group, serum triglyceride (TG) increased (P＜0.05), high density lipoprotein-cholesterol (HDL-C) decreased (P＜0.05), but serum cholesterol and low-density lipoprotein cholesterol (LDL-C) remained unchanged, as compared with those in control group. Serum C-reactive protein (CRP), IL-6 and vascular cell adhesion molecule-1 (VCAM-1) also increased significantly. In MHD group, serum resistin correlated positively with CRP (r=0.387, P＜0.05), IL-6 (r=0.432, P＜0.05), LDL-C (r=0.428, P＜0.05) and subjective general assessment (r=0.517, P＜0.05), and negatively with HDL-C (r=-0.451, P＜0.05). Conclusions MHD patients had higher serum resistin, which may relate to their dyslipidemia, microinflammatory status and cardiovascular diseases
Key words
Maintenance hemodialysis /
Inflammatory factors /
Lipid metabolism /
Cardiovascular disease
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ZHANG Rui;WANG Li;LI Gui-sen.
The correlation of serum resistin to microinflammatory state and dyslipidemia in patients with maintaince hemodialysis[J]. Chinese Journal of Blood Purification. 2008, 7(11): 595-598
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