Experimental study on CA/PEI membrane to the factors relating to liver diseases along with the clearance of bilirubin

LI Lei-lei; DUAN Zhi-jun; JU Jia

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Chinese Journal of Blood Purification ›› 2008, Vol. 7 ›› Issue (12) : 641-643.

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Experimental study on CA/PEI membrane to the factors relating to liver diseases along with the clearance of bilirubin

LI Lei-lei, DUAN Zhi-jun, JU Jia

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Abstract

Objective To study the effect of CA/PEI membrane on cytokines, immunoglubin and complements along with bilirubin clearance in chronic liver diseases. Methods We used CA/PEI membrane to adsorb jaundice sera from 30 cases for 2 hours. Serum IL-6, IL-10, TNF-α and TGF-β1 were measured by ELISA before and after the adsorption. IgA, IgM, IgG, C3 and C4 were detected by immune scatter turbidimetry. Results After the adsorption, serum IL-6, TNF-α and TGF-β1 decreased (P＜0.05), and IL-10, immunoglobulin and complements remained unchanged. Conclusion CA/PEI membrane may affect several cytokines relating to the progress of liver diseases in company with bilirubin clearance.

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Cytokines / Immune index

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LI Lei-lei;DUAN Zhi-jun;JU Jia. Experimental study on CA/PEI membrane to the factors relating to liver diseases along with the clearance of bilirubin[J]. Chinese Journal of Blood Purification. 2008, 7(12): 641-643