Objective　To analyze the incidence for central venous catheter-related bloodstream infections (CRBSI) in hemodialysis patients and improve catheter-related bloodstream infections management using continuous quality improvement (CQI). Methods Analyzing the incidence of central venous catheter-related bloodstream infections (CRBSI) in 68 hemodialysis patients pre-CQI and using CQI to prophylaxis CRBSI. The CQI team was driven by a four-step process called PDCA cycle: plan, do, check and act. Compared the incidence for CRBSI in 76 hemodialysis patients with central venous catheter post-CQI Results　 For untunneled CVCs, The incidence of the total CRBSI is 8.1episodes /1000 catheter-days pre-CQI, and which reduced to 2.6 episodes/1000 catheter-days during the same period post-CQI(decreased 68%).For tunneled CVCs, the incidence of CRBSI dropped from 2.6 episodes /1000 catheter-days pre-CQI to 0.7 episodes /1000 catheter-days post-CQI. Conclusion　Continuous quality improvement program can improve the management of CRBSI in hemodialysis patients.