Abstract: Objective To compare the clearance efficiencies of blood profenofos by hemoperfusion with membrane coated activated charcoal and HA230 absorption resin. Method Profenofos standard solutions were mixed with blood samples from healthy subjects, and the profenofos in blood samples was adsorbed by hemoperfusion through a column containing membrane coated activated charcoal or HA230 absorption resin. The remaining profenofos in blood was then extracted by ethylacetate and determined by capillary gas chromatography. Result The lowest limit for blood methamidophos measurement by this method was 0.8ng. The recovery rate to low, middle and high concentrations of blood profenofos was 95.1%～101.2%, with the relative standard deviation of 1.11%～10.97%. By hemoperfusion using membrane coated activated charcoal column and HA230 absorption resin column, the clearance efficiencies were 78.2%～85.8% and 84.5%～93.8%, respectively. Conclusion Blood profenofos can be cleared efficiently and rapidly by hemoperfusion with membrane coated activated charcoal or HA230 absorption resin.

Key words: Gas chromatography, Hemoperfusion, Membrane coated activated charcoa, HA230 absorption resin