Abstract:

【Abstract】 Objective The aim was to observe the effects of ultrapure dialysate (UPD) on serum interleukin-6, interleukin-1 (IL-1), C-reactive protein, β2-microglobulin, and lipoprotein(a) [Lp(a)]. Methods A controlled prospective randomized study was carried out on 21 stable patients dialyzed on low-flux synthetic polysulphone membrane and assigned to either UPD or conventional dialysate (CD). Blood samples were collected at pre-dialysis, 120 minutes later during the dialysis and immediately post-dialysis. The variables were measured one week before the study, and one week, one month, six months and twelve months during the study. Results All parameters were not changed during the session. Lp(a) was significantly higher in CD group (283.88+145.80 vs 120.90+122.11mg/L, p <0.05), and IL-1βwas lower in UPD group (49.22+14.18 vs 68.05+20.34 pg/ml, p <0.05) at the end of study. Conclusions Biocompatible membrane is first of all to lessen dialysis related chronic inflammation, and ultrapure dialysate should further decrease the high risk of inflammation related atherosclerosis through decreasing IL-1β and preventing rise of Lp(a).

Key words: Hemodialysis, Inflammation, Lipoprotein(a), Interleukin-1β