【Abstract】 Objective To investigate the therapeutic value of continuous blood purification (CBP) in the treatment of severe heart failure patients with renal failure. Methods We retrospectively analyzed 19 cases of severe heart failure complicated with renal failure and treated in our intensive care unit during the period of June, 2003 through Sept., 2007. Blood pressure, heart rate, respiration rate, blood biochemistry, arterial blood gas, oxygenic index (PaO₂/FiO₂) and left ventricle ejection fraction (LVEF) were monitored before and during the treatment. Score of Boston criteria for diagnosing heart failure and APACHE II score were recorded. Results After CBP, heart function were significantly improved in 14 patients with an effective rate of 73.7%. Serum creatinine and blood urea nitrogen decreased quickly, and homeostasis was re-established. The oxygenic index improved gradually, and the score of Boston criteria for diagnosing heart failure and APACHE II score decreased significantly after the treatment. Their vital signs stabilized, and hypotension and arrhythmia were rarely encountered during CBP. Conclusions CBP maintains a stable hemodynamics situation during cleaning excess water and solute. Therefore, CBP is an effective and safe method for the treatment of severe heart failure with renal failure.