【Abstract】 Objective To explore the treatment of crush syndrome complicating acute renal failure after earthquake injury. Methods A retrospective analysis was made on 23 clinical cases of crush syndrome complicating acute renal failure after 5.12 earthquake injury. Results Of 23 cases，1 died of acute pneumochysis; 17 hyperkalemia were rectified; 3 evolved diuresis stage following improved renal function; and clinical symptoms were improved in the other 19. 22 cases were conveied to many hospitals in other provinces after 7～10 days in our hospital. Conclusion It was effective that combined therapy (conventional hemodialysis, continuous renal replacement therapy and others）to treat crush syndrome complicating acute renal failure , and to assist patients overshoot oliguria stage.