Abstract: 【Abstract】 Objectives Arterial stiffness plays a key role in the evolution of cardiovascular diseases. However, it remains unclear if serum uric acid (UA) is related to arterial stiffness in peritoneal dialysis (PD) patients. Methods The relationship between serum UA and arterial stiffness was investigated in 158 stable continuous PD patients. Their clinical and laboratory data were collected, and arterial stiffness was estimated by measuring pulse-wave velocity from right common carotid artery to right femoral artery (CF-PWV). Results Patients were grouped into 4 groups based on serum UA level. C-reactive protein and CF-PWV were different among the 4 groups (P＜0.01). Pearson’s correlation analysis showed that CF-PWV correlated to systolic blood pressure (P＜0.01) and serum UA (P＜0.01). Multivariate regression analysis showed that serum UA (β=-0.300, P=0.001) and calcium-phosphate product (β=0.179, P=0.027) were the independent determinants of CF-PWV. Conclusion Independent correlation exists between serum UA and CF-PWV. Higher serum UA relates to the increase of arterial stiffness, which may contribute to cardiovascular morbidity in PD patients.

Key words: Serum uric acid, Arterial stiffness, Pulse wave velocity