Abstract: 【Abstract】 Objective Non-bioartificial liver has been applied in clinical practice, but the efficacy was reported to be quite different. The aim of this study was to compare the efficacy and safety of plasma exchange (PE) plus continuous venovenous hemodiafiltration (CVVHDF) and hemoperfusion adsorption (HP) plus CVVHDF in the treatment of severe viral hepatitis. Methods Seventy patients with severe liver hepatitis were randomly divided into two groups: patients with single treatment of PE+CVVHDF (36 cases) and those with single treatment of HP+CVVHDF (34 cases). Clinical symptoms and signs, liver function, renal function, prothrombin time (PT), activated partial thromboplastin time (APTT) and electrolytes were analyzed. Results In the 2 groups after the treatment, clinical symptoms improved significantly, serum aminotransferases, total biliruin, urea nitrogen and creatinine decreased (P＜0.01), and serum electrolytes recovered to normal. In the PE+ CVVHDF group after treatment, PT and APTT decreased, and serum albumin increased significantly (P＜0.01), as compared with those of the HE+CVVHDF group. The side effects were mild in all patients in the 2 groups. Conclusion The two artificial liver supporting systems were effective in the treatments of patients with severe liver hepatitis. PE+CVVHDF was better than HP+CVVHDF in improvement of PT, APTT and serum albumin.

Key words: Hemoperfusion, Liver failure, Artificial liver, Continuous venovenous hemodiafiltration