Abstract: 【Abstract】 Object To study bone mineral density at different sites and its correlation to vascular calcification in chronic kidney disease (CKD) patients without dialysis treatment. Methods Bone mineral density (BMD) was measured with dual-energy X-ray absorptionmeter. Vascular calcification was quantitatively evaluated by plain radiographic film from abdomen, pelvis and hands. Biochemical parameters and serum intact parathyroid hormone (iPTH) were assayed. Results (a) In CKD patients at stage 5 without dialysis treatment, the BMD at femora and distal radiuses was lower than that in the patients at stages 3 and 4 and in normal controls (P<0.05), and the BMD at lumbar vertebrates was lower than that in patients at stage 3 and in the normal controls (P<0.05). In CKD patients at stages 3 and 4, the BMD at these sites had no significant differences as compared with that of the normal controls. (b) The prevalence of lower BMD at femora and osteoporosis at radiuses was higher in the CKD patients at stage 5 than in those at stage 3 and in normal controls (P<0.05). (c) In the 100 CKD patients without dialysis treatment, 25 cases were found to have various degrees of vascular calcification at different sites. The BMD at lumbar vertebrates, femora and distal radiuses was significantly lower in the patients with vascular calcification than those without the calcification (P<0.05). Logistic regression analysis showed that the lower BMD at radiuses was the independent risk factor for vascular calcification. Conclusion The BMD at lumbar vertebrates, femora and radiuses was significantly decreased in CKD patients without dialysis treatment at stage 5, but not in the patients at stage 3 and stage 4. Patients with vascular calcification were found to have lower BMD. The BMD at radiuses had closer correlation to vascular calcification than that at other sites.

Key words: Pre-dialysis, Bone mineral density, Vascular calcification