Abstract: 【Abstacts】 Objective To investigate the efficacy of different blood purification method on pruritus in maintenance hemodialysis patients. Methods We randomly assigned 38 maintenance hemodialysis patients into hemodialysis combined with hemoperfusion (HD+HP) group (18 cases) or hemodialysis combined with hemodiafiltration (HD+HDF) group (20 cases). Patients in the HD+HP group were treated with hemodialysis once and hemodialysis combined with hemoperfusion once in a week for 12 weeks, and those in the HD+HDF group were treated with hemodialysis once and hemodialysis combined with hemodiafiltration once in a week for 12 weeks. Before and after the treatment, blood urea nitrogen, creatinine, serum calcium, serum phosphate and iPTH were monitored, and the change of pruritus was evaluated. Results The remission rate of skin itch was higher in HD+HP group (89%) than in HD+HDF group (60%) (P<0.05). The decrease of serum phosphate and iPTH was more prominent in HD+HP group than in HD+HDF group (P<0.05), but the decrease of blood urea nitrogen and creatinine were statistically indifferent between the two groups (P＞0.05). Conclusions HD+HP is more effective than HD+HDF in the treatment of pruritus in maintenance hemodialysis patients.

Key words: Hemodiafiltration, Uremia, Pruritus