【Abstract】 Objective To study the prevalence of peripheral arterial disease (PAD) and its related risk factors in patients on continuous ambulatory peritoneal dialysis (CAPD). Methods We studied 150 CAPD patients with stable clinical status in a single center. Ankle-brachial index (ABI) was measured in these patient, and ABI < 0.9 was considered as having PAD. However, patients with ABI ＞1.3 were excluded because of the false negative rate. Correlation and logistic regression analysis were performed to disclose the risk factors of PAD in these CAPD patients. Results Significant differences in diabetic status, history of cerebro- and cardio- vascular diseases, diastolic blood pressure, blood urea nitrogen, serum albumin, blood sugar and C-reactive protein (CRP) were found between patients with PAD and those without PAD. Logistic regression analysis showed that serum albumin (β= -0.139, P<0.05) and CRP (β＝0.064, P<0.05) were the independent determinants of PAD in CAPD patients. Conclusion Serum albumin and CRP were the determinant factors of PAD in CAPD patients. Therefore, care should be paid to the CAPD patients with malnourishment or inflammation for the prevention of PAD.