【Abstract】Objective To evaluate the effect of high-flux hemodialysis (HFHD) in the survival rate of maintenance hemodialysis (MHD) patients. Methods randomized controlled trials (RCT) and prospective controlled trials (PCT) studying the effect of HFHD on survival rate of MHD patients were searched in the Pubmed / Medline, EMBASE、and Cochrane Library electronic databases, then the odds ratio was calculated. Results 3609 patients in 3 RCT and 2 PCT were included in this study: the effect of survival rate was compared in the HFHD and LFHD group. Compared with the LFHD group, the survival rate of HFHD group wasn抰 improved (Fixed effect model, OR=1.20, Z=1.85, P=0.06，I2=68.1%). There were no significant difference of average admission rate and cardivascular mortality rate between HFHD group and LFHD group. Conclusions HFHD may not improve the survival rate of MHD patients, and it may not reduce the average admission rate and cardiovascular mortality rate of MHD patients.