【Abstract】Objective To research the advantages of pulse high volume hemofiltration in severe sepsis patients. Methods A total of 49 severe sepsis patients were divided randomly into 2 groups: group A, treated with pulse high volume hemofiltration (PHVHF group, n=25); group B, treated with high volume hemofiltration (HVHF group, n=24). APACHE III score, mean artery pressure (MAP), vasoactive drug used, blood coagulation function, biochemistry paameters, inflammation markers were recorded before and after the treatment for 72 hours. The average dialysis time, amount of exchanged dialysate, heparin used, and mortality rate in a 28 day period were compared between the 2 groups. Results After treatment for 72 hours, MAP, norepinephrin used and inflammation markers were similar between the 2 groups (P＞0.05). Compared with patients in group B, patients in group B used more amount of exchanged dialysate, and had shorter dialysis time. decrease of thrombocyte, extend of APTT, decrease of hemoglobin in group B were more obviously than group A (P＜0.05). Conclusions Pulse high volume hemofiltration in severe sepsis patients could had effects similar to continuous high volume hemofiltration. It could save liquids and materials, reduce influences to blood and thromboxane system at the same time.