【Abstract】Objective To investigate life quality and its related factors in hemodialysis patients by using the Kidney Disease Questionnaire (KDQ). Methods We used the KDQ for the investigation in 100 patients on maintenance hemodialysis. Results The scores of PSD and ROD were less in patients than in other dimensions. Life quality of the patients correlated with age, gender, marital status, medical burden, sleep quality, family and social support, and clinical complications. Conclusion More attentions should be paid to psychological care for older and female patients. More work also needs to be done to prevent complications, improve the sleep quality, and communicate frequently with the patients and their families, by which they acquire more supports from their families and societies, and live in a better life quality. It is also advocated to reduce their medical burden.