【Abstract】Objective To investigate the clinical effect of double-filtration plasmapheresis (DFPP) for Waldenstrom macroglobulinemia. Methods We retrospectively analyzed 16 cases with Waldenstrom macroglobulinemia treated in this hospital, and they were divided into DFPP group (8 cases) and routine chemotherapy group (8 cases). Their short-term therapeutic effect was analyzed. Results After 3 months of treatment, serum IgM was remarkably lower in DFPP group than in routine chemotherapy group (P<0.01). Of the 8 cases in DFPP group, 7 were given DFPP combined with chemotherapy, complete remission was found in 2 cases and partial remission in 5 cases; one case was treated with DFPP only without chemotherapy due to damaged liver function, and had no improvement. Of the 8 cases in routine chemotherapy group, partial remission was found in 5 cases, and no remission in 3 cases. Conclusion DFPP is a safe and effective in a short period of time method for the treatment of Waldenstrom macroglobulinemia. DFPP combined with chemotherapy can quickly alleviate the symptoms, improve the biochemical parameters, and achieve better therapeutic effect.