【Abstract】 Objective To investigate correlation of coronary artery calcification score (CACS) with morbidity and mortality of cardiovascular disease (CVD) in hemodialysis patients. Methods Twenty-two patients undergoing maintain hemodialysis (MHD) were enrolled. CACS was determined by electron beam computed tomography (EBCT) in 2002. At 2009-12-31, the relationship of CACS to morbidity and mortality of CVD was analyzed retrospectively. Results In 2002, there were twenty-one patients (95.5%) with coronary artery calcification (CACS＞0). The mean CACS was 1935.54 (0~9833). During a Follow-up period of 7 years, CVD occurred in 17 cases (81.0%) of 21 Patients, and there were 14 deaths (66.7%), of which all was from disease correlated with CVD. Patients with CACS=100 had significantly higher morbidity and mortality of CVD than patients with CACS＜100. High level of hs-CRP and low Alb in group of CACS=100 than CACS<100(P＜0.05). Kaplan-Meier curve demonstrated the average survival time in group of CACS＜100 was longer than group of CACS=100（222.7 vs 111.3M,P=0.042）. Conclusions CACS is correlated with morbidity and mortality of CVD in hemodialysis patients. Microinflammation and malnutrition are important factors. The survival time in group of CACS＜100 was longer than group of CACS≥100.