【Abstract】 Objective Comprehend the action of vitC-containing dialysate on secondary hyperparathyroidism of maintenance hemodialysis Patients. Methods Eighty-two stable maintenance hemodialysis patients were enrolled in the research, fell into two groups randomly. Then we used routine dialysate and vitC-containing dialysate respectively to do hemodialysis,the Period was three months. We examine the contents of iPTH、Ca、P、CaX、ALP 、VitC pre-and post-treatment before hemodialysis.Results The plasma level of iPTH、ALP rose slightly,Ca、P、CaX had no obviously change,VitC descended after hemodialysis with routine dialysate,the difference was statistically significant;but the level of plasma iPTH、ALP were significantly lower than before, the difference was statistically significant, Ca 、P、CaX had no obviously change,VitC rose slightly after hemodialysis with vitC-containing dialysate.Conclusions A lot of vitC can be lost during the hemodialysis with routine dialysate; VitC can reduce the plasma level of iPTH、ALP and prevent the secondary hyperparathyroidism.