【Abstract】Object To investigate the clinical effects and safety of daytime continuous high-volume hemofiltration in patients with multiple organ dysfunction syndrome (MODS) in ICU. Methods We recruited 36 patients with MODS treated in ICU during the period of April 2008 to Sept. 2009. Patients were randomly asigned into continuous normal-volume hemofiltration group (group A, n=16) or daytime high-volume hemofiltration group (group B, n=36). Mortality rate, critical care score, the days staying in ICU, and the days without organ failure within 28 days were compared between the 2 groups. Result There were no difference in mortality rate within 28 days between the 2 groups (25.0% in group A, and 31.25% in group B; 2=0.173, P=0.667). In group A, however, the days without organ failure were longer (18±8 days in group A, and 11±8 days in group B; t=2.21, P=0.036), and the days staying in ICU were shorter (8±5 days in group A and 11±5 days in group B; t=2.30, P=0.029). Conclusion Daytime continuous high-volume hemofiltration is a safe and efficient method for the treatment of MODS in ICU.