Abstract: Objective To study the impact of different blood purification methods on residual renal function (RRF) among maintenance hemodialysis (MHD) patients. Methods Uremic patients on hemodialysis in the Blood Purification Division of this hospital were randomly divided into three groups, low flux hemodialysis (LFHD) group, high-flux hemodialysis (HFHD) group and hemodialysis combined hemoperfusion (HD+HP) group using F6 dialyzer, F60 dialyzer, and F6 dialyzer combined with HA130 blood perfusion dialyzer, respectively. Before the treatment and after the treatments for 6 months, blood and urine specimens were collected, RRF was calculated, and cholesterol, triglycerides, β2-microglobulin (β2-MG) and serum phosphate levels were examined. Results RRF had no significant difference among the 3 groups (P>0.05) before the treatment. After the treatment, RRF was significantly lower than that before the treatment in the 3 groups (P<0.05), RRF was significantly different between HFHD and HD+HP groups and LFHD group (P<0.05), but had no difference between HFHD group and HD+HP group (P>0.05). Serum cholesterol, triglycerides, β2-MG and phosphate levels showed no differences among the 3 groups before the treatment (P> 0.05), became significantly lower in HFHD and HD+HP groups than in LFHD group after the treatment for 6 months (P<0.05), but had no differences between HFHD group and HD+HP group after the treatment for 6 months (P> 0.05). Conclusion RRF declined in hemodialysis patients after dialysis. The decline rate was lower in HFHD and HD+HP groups than in LFHD group, suggesting that HFHD and HD+HP are better than LFHD in the protection of RRF. HFHD and HD+HP also reduced the blood lipids, β2-MG and serum phosphate levels in hemodialysis patients.

Key words: Residual renal function, High flux hemodialysis, Low flux hemodialysis, Hemodialysis and hemoperfusion