Objective Hemodynamic and volume load states are important issues in patients on blood purification. In this study we monitored the hemodynamic status in 235 patients by using the Bioz.com digital noninvasive hemodynamic monitoring system to explore clinical value of this instrument in purification centers. Method A total of 235 hemodialysis patients (65±13 years old) were divided into 3 types: new administers, clinically stable patients and critically ill patients. Hemodynamic variables such as cardiac output (CO), acceleration cardiac index (ACI), thoracic fluid level (TFC) and systemic vascular resistance (SVR) measured by the Bioz.com system were compared with the results from echocardiography and chest X-ray examinations as the golden standards for the same patients and for parallel controls. Results Values of CO and ACI from Bioz.com system were consistent with those from echocardiography. TFC from Bio.com system was positively correlated to the cardio-thoracic ratio from X-ray films and mean arterial pressure (MAP), and SVR was positively correlated to MAP. By using the values from the bio.com system as the therapeutic guidance, maintenance hemodialysis patients showed the decreases of dehydration amount and heart failure frequency, and critically ill patients treated with continuous blood purification displayed lower APACHE Ⅱ score and higher percentage of stable blood pressure period. Conclusion Bioz.com digital noninvasive hemodynamic monitoring system provides multiple, reliable and clinically significant data for determining cardiac function status, volume load capacity, dry body weight and dehydration amount. It is a useful monitoring instrument in the field of blood purification.